Charge matters: PTA-based ligands in palladium anticancer complexes

Read here our latest article in RSC Advances. It focuses on the influence of the charge of PTA-based ligands on the anticancer activity of organopalladium complexes. This study highlights how subtle electronic changes can significantly affect biological performance.

Congratulations to all the people involved!

First Gold–NHC Complexes Reported as Ferroptosis Inducers

In collaboration with the Karges group, we report the first examples of gold–NHC complexes acting as ferroptosis inducers. This study expands the therapeutic potential of metal-based compounds by targeting a regulated form of cell death distinct from apoptosis. You can read it here.

Curious About Gold–PTA Complexes in Catalysis and Anticancer Applications?

Here you can find our latest work concerning the catalytic and anticancer properties of gold complexes bearing PTA-based ligands. The study focuses on the peroxidative oxidation of cyclohexane, evaluated under both homogeneous and heterogeneous conditions (the latter using carbon nanotubes as support).

Palladium Complexes Triggering Immunogenic Cell Death

We are proud to present our latest research on a new class of palladium-based compounds capable of inducing immunogenic cell death (ICD) in cancer cells. These complexes do not merely eliminate tumor cells , they also activate the immune system, promoting a long-lasting antitumor response.You can read it here.

Welcome Mirco!

It’s a pleasure to introduce you to Mirco, the new post doc researcher of the group.

If you want to find out more about the people who make up the entire group, read here.

First 2025 paper about metal-based anticancer agents!

Here you can find the synthesis of Gold and Palladium complexes bearing NHC thioglucosides that exhibit selective anticancer Activity.

Are you interested in Palladium(II) coordination of N-heterocyclic carbene ligands with a triazole moiety?

Here a series of N-heterocyclic carbene (NHC) palladium complexes derived from N-methyl or N-mesityl-imidazolium salts bearing a triazole ring as pendant group to the second nitrogen atom, have been synthesized and characterized.

Are N-heterocyclic carbenes involved in your research activity?

Here you can find a revisitation of the weak base route mechanism concerning the synthesis of metal-NHC species. Moreover, aqueous NH₃ is presented as a new and greener weak base.

Rim-brominated pillarplexes and their assembly via self-sorting.

Dalton Trans., 2024, Advance article.

Our recent article published on Dalton Transaction has been highlighted with the internal front cover of the issue!

Dalton Trans., 2024, 53, 18058-18058

Are you interested in using machine learning platforms for optimizing new catalytic systems?

Here you can find our work, in collaboration with the Nolan group, dealing with the ML directed amide reduction with Pt precatalysts

Very happy to share our work on N-Methylation of amine with CO₂ using Cu(II) organometallic catalyst precursors!

Giammarco Meloni, Luca Morgan, David Cappelletti, Matteo Bevilacqua, Claudia Graiff, Piermaria Pinter, Andrea Biffis, Cristina Tubaro and Marco Baron.

Dalton Trans., 2024,53, 18128-18140

DOI https://doi.org/10.1039/D4DT02936D

Welcome to Davide and Federico as PhD students!

You can find more information about the team in the specific section Group.

Two EurJICs are better than one!

This month, two new papers from our group have been published in the European Journal of Inorganic Chemistry. Both articles examine the novel category of Pd-butadienyl complexes as promising antitumor agents. Specifically, the first paper reports the synthesis of complexes bearing picoly-NHC and phosphine ligands (read here), while the second article focuses on heterobimetallic Fe/Pd complexes containing butadienyl fragments with different halides as terminal groups (read here). This second story was developed in collaboration with Gasser Group (ChimieParisTech, Paris).

Talk about the coumarin synthesis

Are you interested in gold(III) catalysis? Here you can find our work on coumarin synthesis in the presence of ionic liquids.

While, here you can find our latest work dealing with the synthesis of coumarins with an improved gold-based catalytic system.

Second ChemicalScience of this 2024!

This time we have investigated the impact of both steric and electronic properties of TADF emitters in electochemiluminescence. Many thanks to Valenti group and all the team!

What a wonderful way to end this fruitful August!

In collaboration with Hashmi group we have reported in Chemical Science an elegant synthetic route to Au/Pt (orPd) complexes and their anticancer activity!

What a fruitful August!

Are you interested in how to conjugate metallodrugs or natural compounds to monoclonal antibodies? Here you can find our review on the topic, with a focus on Antibody Drug Conjugates for Cancer Therapy.

Here in we describe the synthesis, in vitro, ex vivo and in vivo anticancer activity of Pd-NHC indenyl complexes and their mode of action on ovarian cancer.

The last, but not the least…Another stellar review from our group is now online and you can read it here! This time we have described how metallodrugs can be encapsulated into liposomes with the aim of improving their anticancer properties! Congrats to all the team!