Palladium(0) and Juglone: a new alliance in the fight against ovarian cancer

Giovanni Tonon, Anna Rafaniello, Matteo Mauceri, Nicola Demitri, Thomas Scattolin, Flavio Rizzolio, Fabiano Visentin

DOI: DOI https://doi.org/10.1039/D5DT01792K

Dalton Trans., 2026, 55, 445-459

Facile and green synthesis of [Pd(NHC)(η³-R-allyl)Cl] complexes and their anticancer activity

Riku Saito, Pierre Arnaut, Benon Maliszewski, Laura Tripodi, Isabella Caliguri, Flavio Rizzolio, Thomas Scattolin, Steven P. Nolan

DOI: https://doi.org/10.1039/D5DT01326G

Dalton Trans., 2025, 54, 11720-11724

Mannose-Inspired Mesoionic Carbenes: Building Antitumor Palladium(II) Allyl Complexes

Giovanni Tonon, Martina Scianna, Isabella Caligiuri, Flavio Rizzolio, Fabiano Visentin, Thomas Scattolin

DOI: https://doi.org/10.1002/ejic.202500382

European Journal of Inorganic Chemistry, 2025, 28(29), e202500382

Exploring the anticancer properties of indenyl and allyl palladates through their interaction with nucleic acids

Tommaso Giani, Giannantonio Tomasi, Pablo A. Nogara, Laura Orian, Fabiano Visentin, Thomas Scattolin, Tarita Biver

DOI: https://doi.org/10.1016/j.jinorgbio.2025.112978

Journal of Inorganic Biochemistry, 2025, 271, 112978

A new generation of N-heterocyclic carbene (NHC) gold-selenolato complexes as potent anticancer agents: distinct synthetic routes and evaluation in 2D and 3D cancer models

Pierre Arnaut, Nestor Bracho Pozsoni, Denys Bondar, Petra Lippmann, Susanne Boschuk, Ivan Semenyuta, Subhrajyoti Bhandary, Kristof Van Hecke, Yevgen Karpichev, Enrico Cavarzerani, Vincenzo Canzonieri, Flavio Rizzolio, Thomas Scattolin, Georgios C. Vougioukalakis, Ingo Ott, Nikolaos V. Tzourasaj and Steven P. Nolan

DOI: https://doi.org/10.1039/D5SC04490A

Chemical ScienceOpen source preview, 2025, 16(37), pp. 17221–17231

Gold(I) complexes with NHC ligands functionalized with sulfoxide groups: Design, synthesis, in vitro studies and insights into the mechanism of action as anticancer drugs

Eleonora Zampieri, Chiara Donati, Victoria Mechrouk, Thierry Achard, Stéphane Bellemin-Laponnaz, 

Alessandro Dolmella, Cristina Marzano, Marco Baron, Valentina Gandin, Cristina Tubaro

DOI:https://doi.org/10.1016/j.jinorgbio.2025.112957

Journal of Inorganic Biochemistry, 271 (2025) 112957.

Expanding the Chemical Space of Allyl Palladates with Anticancer Properties

Alessia Schiavo, Giacomo Baio, Francis Bru, Irene Guerra, Victoria Mechrouk, Thierry Achard, Sara Baldissin, Stéphane Bellemin-Laponnaz, Catherine S. J. Cazin, Cristina Tubaro, Fabiano Visentin, Isabella Caligiuri, Flavio Rizzolio, Steven P. Nolan, Thomas Scattolin.

DOI:https://doi.org/10.1002/ejic.202500146

Eur. J. Inorg. Chem. 2025, 28, e20250014.

Investigation of the in vitro anticancer potential of bis(imino)acenaphthene–N-heterocyclic carbene transition metal complexes revealed TrxR inhibition and triggering of immunogenic cell death (ICD) for allyl palladates.
Chiara Donati, Ishfaq Ibni Hashim, Nestor Bracho Pozsoni, Laurens Bourda, Kristof Van Hecke, Catherine S. J. Cazin, Fabiano Visentin, Steven P. Nolan, Valentina Gandin and Thomas Scattolin.
DOI:https://doi.org/10.1039/D5MD00039D
RSC Med. Chem., 2025, Advance Article.

Exploring the catalytic and anticancer activity of gold(I) complexes bearing 1,3,5-triaza-7-phosphaadamantane (PTA) and related ligands.

Nuno Reis Conceição, Abdallah G. Mahmoud, Martin C. Dietl, Isabella Caligiuri, Flavio Rizzolio, Sónia A. C. Carabineiro, Matthias Rudolph, M. Fátima C. Guedes da Silva, Armando J. L. Pombeiro, A. Stephen K. Hashmi and Thomas Scattolin.

DOI:https://doi.org/10.1039/D5NJ01194A

New J. Chem., 2025,49, 7216-7226.

Gold(I) N-Heterocyclic Carbene Complexes as Ferroptosis Inducing Anticancer Agents

Evelyn Schlegel, Zisis Papadopoulos, Nicolás Montesdeoca, Vladislav A. Voloshkin, Steven P. Nolan, Stephan A. Hahn, Thomas Scattolin,Johannes Karges.

DOI:https://doi.org/10.1021/acsmedchemlett.5c00096

ACS Med. Chem. Lett. 2025, 16, 5, 856–864.

Influence of the charge of 1,3,5-triaza-7-phosphaadamantane-based ligands on the anticancer activity of organopalladium complexes

Tommaso Lorenzon, Maria Vescovo, Michele Maiullari, Giovanni Tonon, Nuno Reis Conceição, Sónia A. C. Carabineiro, Abdallah G. Mahmoud, Martin C. Dietl, Nicola Demitri, Laura Orian, Pablo A. Nogara, Isabella Caligiuri, Flavio Rizzolio, A. Stephen K. Hashmi, Fabiano Visentin and Thomas Scattolin.

DOI:https://doi.org/10.1039/D5RA02119G

RSC Adv., 2025,15, 14058-14071.

Synthesis of Gold(I) and Palladium(II) Complexes Bearing N-Heterocyclic Carbene Thioglucosides with Selective Cytotoxicity Towards Ovarian Cancer Cells.
Francis Bru, Maxime Vanwynsberghe, Eleonora Botter, Giovanni Tonon, Fabiano Visentin, Alessia Schiavo, Flavio Rizzolio, Catherine S. J. Cazin and Thomas Scattolin.
DOI:https://doi.org/10.1002/ejic.202400822
Eur. J. Inorg. Chem. 2025, e202400822.